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The Arcade Fire frontman said that although the U2 star's approach 'wasn't his path', he 'forever credits him' for "engaging" with the former US president.
Butler told NME: "As much as people slag Bono, I will forever give him credit for engaging with George W. Bush when he was president. Even though it was a deeply unpopular move, even in his own band.
"The HIV medications in Africa, every aspect of the US foreign policy - it was a hell of a lot more than any president before had done."
He added: "Bono was engaged in the work even though the situation wasn't ideal. That's not my path, but I will never fault someone for trying to be engaged in the world."
In 2003, Bono called Bush "bold" for increasing the US's Emergency Plan for Aids Relief budget in Africa and the Caribbean.
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