Cruz's ninth UK single has gained a significant lead on Eminem and Rihanna's 'Love The Way You Lie', which remains in second place.
If the song manages to retain its lead, it would give Cruz his second number one single.
The second highest new entry is Katy B's 'Katy On A Mission' at number five, while Brandon Flowers's debut solo effort 'Crossfire' currently sits in eighth place.
Further down the chart, Hurts are at 18 with 'Wonderful Life' and Aggro Santos debuts at 19 with 'Saint Or Sinner'.
On the album chart, Eminem has climbed a place back to number one with Recovery, fighting off competition from Plan B, whose sophomore LP The Defamation Of Strickland Banks climbs up to two.
The Klaxons' Surfing The Void has entered the chart at four, while The Saturdays have so far slipped six places to nine with Headlines!.
The official chart positions will be announced on Sunday between 4pm and 7pm.
Source: Official Charts Company