The LCD Soundsystem star revealed his attitude to NME before the band's performance at Leeds Festival.
He said: "I don't give a s**t about Guns N' Roses except for [bassist] Tommy Stinson, which I feel weird about."
Murphy added of his set on the festival's final day: "Sunday is a tough one because everyone is a little tired and beat-up. You have to just appreciate and remember the audience is a little tired. So you have to give them a break."
He later addressed his audience: "We really do appreciate this. You guys must be f**king tired. Why don't you stay with us instead of going to see the Guns N' Roses man?"