The band, who today announced details of their Children In Need single, won 'Best Group' and 'Best Video' for their former number one hit 'Everybody In Love'.
Cheryl Cole also took home two awards, scooping 'Best Single' with 'Fight For This Love' and 'Best Female'.
Tinie Tempah, who is on course for his second number one single this Sunday with 'Written In The Stars', won the 'Best Newcomer' prize.
He told Bang Showbiz: "This means a lot because digital music is my generation, how I grew up - listening to and finding new music through the internet, as well as coming up through it.
"To be recognised by the people who have voted means a lot."
Other artists who picked up gongs included Robbie Williams for 'Best Male' and Gorillaz for 'Artist of the Year'.
Marina and The Diamonds, McFly and London-based grime collective Roll Deep were among acts who performed on the night.
The awards will be broadcast on ITV2 on October 2.