The conceptual artist was widely criticised when she and Lennon started their relationship in 1966. Ono was blamed by some for the split of The Beatles four years later.
Burgess, lead singer in The Charlatans, told ShortList: "She's come in for so much flak, but I believe Yoko was the best thing that ever happened to John. The politics and the sit-ins were her influence, and she led him over a threshold and took him on to somewhere else.
"He'd perfected his pop side but I don't think he had the confidence to explore his experimental side until he met Yoko - she taught him that art and politics could intertwine."
He added: "People don't realise just how powerful the combination was with her John and Yoko, that's why people blame her for splitting The Beatles. Even [Paul] McCartney's natural reaction was to blame. He's only now coming to terms with their love, that it was real.
"I loved the era when John was going on TV with Yoko and defending her as a woman. People said really terrible things about her and he defended her in front of millions, telling the world to f**k off."
This year, Ono marked what would have been Lennon's 70th birthday. The Beatles singer was shot dead on December 8, 1980.