The singer, who is currently in Australia to promote her sophomore album The Gift, said she is "ready" to take on the group, who are the country's most successful rock act ever.
Asked if she would consider covering one of their tracks on Shane Warne's chat show Down Under, she said: "You want? You got, let's move. No problem, come on lads, I'm ready when you are."
The 'Wild Horses' star then put on deep voice and joked: "I'm headbanging as well."
Boyle is currently leading the US album chart for a fourth week. The Gift has sold almost 2 million copies worldwide.