The trio took home five trophies from Sunday night's ceremony, including 'Record Of The Year' and 'Song Of The Year' for their track 'Need You Now'.
Speaking to AFP backstage, singer Hillary Scott said: "We are completely floating ... We're on a cloud... It is just the most humbling feeling in the entire world."
She added to reporters: "We really wanted to make Nashville and the country community proud tonight, and I hope they feel that way. I think it just shows that country music is relevant, and it's relatable.
"I just hope they think we're flying the flag right."
The group also picked up prizes for 'Best Country Song', 'Best Country Performance By A Duo/Group' and 'Best Country Album'.
Lady Antebellum also posted a video on their official Twitter account following the ceremony, thanking fans for their support. "This night has completely changed our lives," said Dave Haywood. "Now we celebrate!"
> Grammy Awards 2011 - The Winners