The rapper tops the bill at the Wembley Arena show on July 31, with support from Shaggy, Sean Paul, Aswad, Ky-Mani Marley, Skepta, Gyptian and others BBC Newsbeat reports.
Rhymes said: "I can't wait to get back to the UK. It's been three years since I last performed here so I'm dying to tear the roof off Wembley Arena.
"When I'm done, you're gonna remember it for a long time to come. Get ready because it's about to go down."
Tickets for the event are available now and are priced from £35-£55.
The gig is the first One Love Peace Festival in the capital for 20 years and marks the 30th anniversary of the death of Bob Marley.