According to the Press Telegram, the hip-hop musician's family confirmed that he passed away on Tuesday, March 15. No further details have yet been released.
Born Nathaniel Dwayne Hale in August 1969, the Grammy-nominated singer found fame with Warren G on 'Regulate' in 1994. He also collaborated with a multitude of musicians including Snoop Dogg, Eminem, Dr Dre and Mark Ronson.
A series of posts on Snoop Dogg's official Twitter account read: "We lost a true legend n hip hop n rnb. One of my best friends n a brother to me since 1986 when I was a sophomore at poly high where we met.
"I miss u cuzz I am so sad but so happy I got to grow up wit u and I will c u again n heaven cuz u know d slogan... all doggs go to heaven yo homie n baby brotha bigg snoopdogg!! (sic)"
Hale had experienced health problems in recent years and had two strokes in 2007 and 2008.