The Gossip frontwoman, who released her self-titled debut solo EP last week, defended her band against being labelled a one-hit wonder.
When asked if she was worried about the accusation, she responded: "Not really, because we're big in places that don't even know about 'Standing in the Way of Control'.
"Music for Men sold more than a million copies worldwide - just not so well in the UK. But the UK is so fickle anyway."
Ditto went on to explain her views on Lady GaGa's pro-gay rights perspective.
"For my group of friends is Lady GaGa eye-opening? No," she told The Guardian.
"She's a less dangerous version of what was so cool about pop culture in the '80s. Back then it was so gay and so punk in so many ways.
"The idea that Prince - Prince! - could be the look and sound of a decade is f**king awesome. But I still think GaGa's great because she embodies that spirit a little bit."
Ditto had previously said that she felt the Gossip's 'Standing in the Way of Control' was a fluke.