The singer, who releases her seventh studio album Femme Fatale on Monday, performed tracks from the LP including 'Hold it Against Me', 'Till the World Ends' and 'Big Fat Bass' at Rain Nightclub in the Palms Casino Resort.
"Looks like my little secret isnt a secret anymore. Whos coming to watch me take the stage TONIGHT at @RainLasVegas at @PalmsLasVegas? (sic)" Spears teased on Twitter prior to the show. "You're all invited. Be there or be square bitch!"
"We are extremely excited to have one of the most iconic artists of all time back at the Palms," owner George Maloof said. "Britney's performances were unbelievable and her fans will never forget this night."
Following the show, Spears said on Twitter: "OMFG it feels good to be on stage again!"
Jersey Shore star and Palms Casino Resort resident DJ Pauly D warmed the crowd up ahead of the show.