The 'New Blood' jaunt will celebrate the 25th anniversary of the release of his landmark album So, which featured several of the singer's most popular tracks, including 'Red Rain' and 'In Your Eyes'.
Aside from performing tracks from his latest LP, Gabriel and his conductor Ben Foster will also lead the New Blood Orchestra in reworked versions of the musician's biggest hits. Foster has previously acted as the orchestrator for the sci-fi series Doctor Who.
The British singer's upcoming tour will stop in Chicago, Toronto, Boston and Houston among other cities in the US and Canada.
The gigs will mark Gabriel's first concerts since undertaking a limited series of live dates last year upon the release of his eighth studio album Scratch My Back, which was composed of covers of songs made famous by David Bowie, Talking Heads and Neil Young.
Gabriel first gained fame as the frontman of Genesis in the early 1970s, later leaving the group for a solo career. He has since scored eight US top 40 albums and founded the successful WOMAD festival.
The 'New Blood' concert series kicks off with a special gig at The Greek Theatre in Berkeley, CA on June 10.
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Watch Peter Gabriel perform 'In Your Eyes' below: