The music network announced that the rapper will be joined by Far East Movement and LMFAO on the billing for the show, which will take place on the island on June 30.
Snoop commented: "MTV always throws a good party, and Isle of MTV is one of the best nights of live music in Europe over the summer. I plan to rock the Il-Fosos this June like that Square has never seen before."
The event is now in its ninth year and has seen past performances from the likes of Lady GaGa, Black Eyed Peas and Gorillaz.
Snoop recently revealed that he sees his collaborations with other artists as "an honour".
Listen to Snoop Dogg and Charlie Sheen's track 'Winning' below: