The 'Edge Of Glory' singer's long-awaited sophomore LP shifted over 215,000 copies since its release on Monday to bump album chart dominator Adele's 21 and 19 records into second and third place respectively.
Commenting on her success, the 25-year-old gushed: "I feel so honoured to have the highest first-week sales in the UK this year. I wrote the album's first single 'Born This Way' in Manchester because I was so inspired by the confidence and bravery characteristic of my fans, little monsters. To the United Kingdom, thank you for believing in me."
Elsewhere in the rankings, veteran dance collective The Prodigy score their seventh Top 10 album with World's On Fire - Live at five, while GaGa's debut offering The Fame shoots to seven from last week's 11 following Born This Way's arrival.
Meanwhile, Kate Bush manages to snatch just one week in the top 10 after latest album Director's Cut slides nine spots to 11, finishing just ahead of Frankie Valli & The Four Seasons collection Working My Way Back To You, a new entry at 12.
Aloe Blacc continues to collect fans as his Good Things LP climbs from 26 to 14, while Take That's multi-million-selling Progress jumps five places to 16 after the launch of their record-breaking live tour in Sunderland on Friday.
Finally, the Foo Fighters slip nine places to 18 with Wasting Light, Friendly Fires land at 19 from last Sunday's six with Pala and Fleet Foxes conclude the top 20 after Helplessness Blues crashes eight places from 12.
The Top 10 in full:
1. (-) Lady GaGa: 'Born This Way'
2. (1) Adele: '21'
3. (3) Adele: '19'
4. (5) Bruno Mars: Doo Wops & Hooligans'
5. (-) The Prodigy: 'World's On Fire - Live'
6. (8) Jessie J: 'Who You Are'
7. (11) Lady GaGa: 'The Fame'
8. (4) Hugh Laurie: 'Let Them Talk'
9. (7) Chase & Status: 'No More Idols'
10. (10) Caro Emerald: 'Deleted Scenes From The Cutting Room Floor'
Source: Official Charts Company
> This week's singles chart
Watch 'Judas' from Lady GaGa's number one album Born This Way below:
View the latest Official Top 100 Album Chart