The pop four-piece debuted the track last week ahead of its release on July 24. The single is the product of a £30,000 recording session with Lady GaGa producer RedOne and features vocals from up-and-coming female emcee Dev, who is best known for featuring on Far East Movement hit 'Like A G6'.
JLS are expected to perform the track during the results show of tonight's Britain's Got Talent.
'She Makes Me Wanna's music video was shot in Miami last month with band member Marvin Humes describing it as "hot".
The group will release their as-of-yet untitled third studio album later in the year.
> JLS: 'We're in this for the long haul'
Listen to 'She Makes Me Wanna' by JLS below: