A tax protest group from Art Uncut will attend U2's performance on June 24 to campaign against the group's "convoluted" tax affairs.
U2 moved a portion of their business affairs from Ireland to the Netherlands in 2006, reportedly in order to avoid a limit on lucrative tax breaks for artists in the republic.
The protest group have said that they do not intend to interrupt the band's performance, but hope to make sure their message is visible.
They plan to to float a large bundle of cash from one section of the crowd under an Irish flag to another section under a Dutch flag.
An Art Uncut spokesperson said: "Bono claims to care about the developing world, but U2 greedily indulges in the very kind of tax avoidance which is crippling the poor nations of this world."
A spokesperson for Bono's anti-poverty group One, responded: "U2's business arrangements have nothing to do with illegal tax evasion and transfer mispricing in developing countries, critical issues which Bono and One campaign on."
U2's Adam Clayton has said that they hope to put "Glastonbury on steroids" this June.
RedOne is currently working with U2 on a "futuristic" new album.