The 25-year-old performer took the number one and number three positions on the most played songs list of last year, which was compiled by royalties body PPL.
GaGa's 'Bad Romance' topped the chart, being named the song most played on radio and in public spaces. The entertainer's second entry came in the form of 'Alejandro', which placed at three.
Alicia Keys took the runner-up position with her solo rendition of 'Empire State of Mind (Part II)' landing at number two.
Plan B was crowned the most played British act with his single 'She Said' named on the list in fourth position, followed closely by Kylie Minogue's 'All The Lovers' at five.
Commenting on the list, PPL chairman Fran Nevrkla said: "The pop songs are truly modern classics, instantly recognisable and a great representation of the British public's appetite in the past year."
GaGa recently set the record for the fastest-selling album of 2011 globally so far with her sophomore record Born This Way.
The top 10 most played songs of 2010 are as follows:
1. Lady GaGa - 'Bad Romance'
2. Alicia Keys - 'Empire State of Mind (Part II)'
3. Lady GaGa - 'Alejandro'
4. Plan B - 'She Said'
5. Kylie Minogue - 'All The Lovers'
6. Olly Murs - 'Please Don't Let Me Go'
7. Ke$ha - 'Tik Tok'
8. Florence and the Machine - 'Rabbit Heart (Raise It Up)'
9. Train - 'Hey, Soul Sister'
10. Kings of Leon - 'Sex On Fire'
Watch the video for Lady GaGa's 'Bad Romance' below: