The track, which sold 188,000 downloads last week, continues to fight off competition from Pitbull, who remains at two with 'Give Me Everything', while LMFAO's 'Party Rock Anthem' completes the top three.
Meanwhile, Katy Perry's 'Last Friday Night' leaps from 31 to four, while Lady GaGa's 'Edge of Glory' remains at number six.
Jason Aldean's 'Dirt Road Anthem' advances from nine to seven, Nicki Minaj's 'Super Bass' motors from ten to eight, and Lupe Fiasco's 'The Show Goes On' returns to the Top 10 at ten.
Further down the chart, Bad Meets Evil - the duo of rappers Eminem and Royce Da 5'9 - land at 16 with 'Lighters'.
Three The Voice contestants also debut on the tally: Javier Colon at 64 with 'Angel', Vicci Martinez's 'Jolene' at 76 and Casey Weston's 'Black Hourse and the Cherry Tree' at 90.
The Top 10 singles in full (click where possible for our reviews):
1. (1) Adele: 'Rolling in the Deep'
2. (2) Pitbull ft. Ne-Yo, Afrojack and Nayer: 'Give Me Everything'
3. (3) LMFAO ft. Lauren Bennett & GoonRock: 'Party Rock Anthem'
4. (31) Katy Perry: 'Last Friday Night'
5. (4) Katy Perry ft. Kanye West: 'E.T.'
6. (6) Lady GaGa: 'The Edge of Glory'
7. (9) Jason Aldean: 'Dirt Road Anthem'
8. (10) Nicki Minaj: 'Super Bass'
9. (5) Bruno Mars: 'The Lazy Song'
10. (11) Lupe Fiasco: 'The Show Goes On'
Watch the video for Adele's 'Rolling in the Deep' below: