The 'Heartbreak Warfare' musician was once an avid Twitter user, but closed his account last year because he had "no more interest" in the social networking website.
Mayer elaborated on his reasons for quitting Twitter during a symposium at Berklee College of Music, when he told students that composing witty observations in under 140 characters altered his approach to composing music.
"I realised about a year ago that I couldn't have a complete thought anymore, and I was a tweetaholic," he joked. "I had four million Twitter followers, and I was always writing on it. And I stopped using Twitter as an outlet and I started using Twitter as the instrument to riff on, and it started to make my mind smaller and smaller and smaller. And I couldn't write a song."
The singer explained that he is attempting to devote his entire focus on crafting tracks for his upcoming fifth solo album now that he's quit social media.
Mayer explained: "Here are the rules for recording this record: No drum machines, no loops, no keyboards to start out with, no excuses, no breaks, no laptops, no nothing. If you take a break, it's to eat. If you're done, you go home."
His last platinum-selling release Battle Studies spawned the US top 40 hits 'Who Says', 'Heartbreak Warfare' and the Taylor Swift duet 'Half of My Heart'.
Mayer, Coldplay, Lady GaGa, Steven Tyler and Nicki Minaj have all signed on to perform at Ryan Seacrest's Las Vegas iHeartRadio Music Festival.
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Watch John Mayer perform a medley of his hit 'Clarity' and Michael Jackson's 'Human Nature' below: