The group will also be backed by Trevor Moss and Hannah Lou, organisers Robin and Joe Bennett's band The Dreaming Spires and other special guests during the final performance at the Oxfordshire festival on July 24.
The Truck Hill Festival takes place at Hill Farm, Steventon from July 22 to July 24, and will also feature the likes of Gruff Rhys, Graham Coxon and The Go! Team.
Rumours has sold over 40 million copies worldwide, and contains the hits 'The Chain', 'Dreams' and 'Go Your Own Way'.
The album also recently featured as the first album to have an entire episode of Glee dedicated to it.
Watch Fleetwood Mac perform 'Dreams' below: