The singer will allegedly release 'You and I' as the fourth track to be lifted from her multi-million-selling album Born This Way.
The track was produced by AC/DC collaborator Robert John Lange and features electric guitar from Queen's Brian May.
It also samples the beat clap from Queen's iconic hit 'We Will Rock You'.
GaGa included the song as part of the setlist for a number of her final 'Monster Ball' shows, which came to a close back in May.
A video for the single is currently being filmed in Springfield, Nebraska in the US, where onlookers claim to have seen GaGa perform the track with a piano in the middle of a cornfield.
The 25-year-old performer recently revealed that her father hired a stripper to teach her the piano when she was younger.
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Listen to Lady GaGa's new single 'You and I' below:
Watch the news report on the filming of the 'You and I' music video below: