The track, which features New Zealand singer Kimbra, spends a second week atop the tally, while Maroon 5 and Christina Aguilera's 'Moves Like Jagger' remains at two and Adele's 'Someone Like You' completes the top three.
Meanwhile, LMFAO's 'Champagne Showers' lifts from 10 to nine and David Guetta and Sia's 'Titanium' vaults from 31 to ten.
Outside the top ten, Jason Derulo's 'It Girl' debuts at 16, and These Kids Wear Crowns leaps 23 to 17 with 'Jumpstart'.
Cobra Starship and Sabi's 'You Make Me Feel' advances from 43 to 29, and Lady GaGa's 'You & I' starts at 34.
The Top 10 singles in full (click where possible for our reviews):
1. (1) Gotye ft. Kimbra: 'Somebody That I Used To Know'
2. (2) Maroon 5 ft. Chrisitina Aguilera: 'Moves Like Jagger'
3. (3) Adele: 'Someone Like You'
4. (4) Jessica Mauboy: 'Inescapable'
5. (7) Adele: 'Rolling In The Deep'
6. (6) Nicki Minaj: 'Super Bass'
7. (5) LMFAO ft. Lauren Bennet & GoonRock: 'Party Rock Anthem'
8. (8) Nicole Scherzinger ft. 50 Cent: 'Right There'
9. (11) LMFAO ft. Natalia Kills: 'Champagne Showers'
10. (31) David Guetta ft. Sia: 'Titanium'
Watch Gotye's 'Somebody That I Used To Know' video below: