The 'You and I' singer will open the telecast later this month at the Nokia Theatre in Los Angeles.
While GaGa would not reveal the details of her performance, she told MTV News: "I would say that my life is one continuous performance and that, in a way, all performances of mine relate to one another. And you will not be disappointed."
The Born This Way star received nominations in four categories at this year's MTV Video Music Awards, including 'Best Art Direction' and 'Best Choreography' for 'Judas' as well as 'Best Female Video' and 'Best Video With A Message' for 'Born This Way'.
The MTV Video Music Awards 2011 will be broadcast live on Sunday, August 28 at 9pm ET/PT.
> Lady GaGa: 'You and I video captures spirit of song'
Watch Lady GaGa's video for 'You and I' below: