The singer, who is up for four awards, will also perform at the show, which takes place at LA's Nokia Theatre on August 28.
The new promo sees the 'Grenade' singer stroll through a party, engage in a spot of DJing and play the piano.
Britney Spears will be honoured with a 'Lifetime Achievement' award at this year's ceremony and reports have suggested that Madonna and Katy Perry will be among a host of stars who will perform a medley of the 29-year-old's hits.
Tony Bennett will be on hand to pay tribute to the late Amy Winehouse, while Lady GaGa, Adele, Chris Brown and Beyoncé will also perform.
The MTV Video Music Awards air live on Sunday, August 28 at 9pm ET/PT.
Watch Bruno Mars's MTV VMAs 2011 promo below: