The band will perform their back catalogue of hits at the concert, which will take place at London's O2 Arena on December 17.
Bassist Nicky Wire revealed that they will play all 38 singles included on their new compilation National Treasures, which is due out on October 31.
Wire told NME: "We've never done anything on this scale before, so we'll be playing for an hour and a half, then there will be a half-an-hour interval, with lots of stuff, film stuff to do. And then we'll finish with another 20 songs."
He added: "It's going to be an immense project, production-wise, screens, videos, you name it. It will be a completely unique thing and we'll never do it again."
Tickets for the one-off gig will go on sale on September 2 at 9am.
Watch the music video for the Manic Street Preachers hit 'The Masses Against The Classes' below: