The singer was due to sing at the award show, which will be held at London's Grosvenor House Hotel.
However, the 'Set Fire To The Rain' star has pulled out of the event due to bronchitis, after cancelling two of her UK tour dates last week.
Adele is nominated for the prestigious £20,000 prize for her second studio album 21.
It was recently confirmed by the ceremony organisers that all of the 12 nominees would perform at the show, in what would have been a first for the award ceremony.
Adele faces tough competition for the prize, with this year's nominees including Tinie Tempah, Katy B, Elbow, PJ Harvey, King Creosote & Jon Hopkins, Everything Everything, Metronomy, Anna Calvi, Gwylim Simcock, Ghostpoet and James Blake.
BBC Two and the BBC HD channel will broadcast the ceremony from 10pm, while 6 Music will be live from the event from 8pm.
Lauren Laverne will host the BBC coverage, while Jools Holland will present the main awards show.
Albums released between July 2010 and July 2011 are eligible for this year's prize, which is voted for by a panel of music industry leaders and experts.
Watch Adele perform her recent single 'Set Fire To The Rain' below: