The Chili Peppers have had numerous lead guitarists since they formed in 1983, with John Frusciante, Dave Navarro and Hillel Slovak playing for the band at various times.
Drummer Smith said that he is confident Klinghoffer will bring stability to the Red Hot Chili Peppers.
"The guitar player spot in our group is... We've had a few. We're like Spinal Tap," Smith joked to Rolling Stone.
Smith added: "Things are really good with the band right now, and we just got our feet wet with these shows. It's really a new band. Me, Flea and Anthony have been obviously playing together for a while - but this is exciting and it re-energised everybody."
The Red Hot Chili Peppers' latest album I'm with You reached the top spot on the UK album chart and hit the top five in the US.
Smith previously joked that people often confuse him for Anchorman actor Will Ferrell.
> Red Hot Chili Peppers: 'Josh Klinghoffer has changed our sound'
Watch the music video for the Red Hot Chili Peppers' hit 'The Adventures of Rain Dance Maggie' below: