The 10-year-old has teamed up with rapper Nicki Minaj for 'Fireball', which is expected to be released in the coming weeks.
The singer teased the release of the song on Twitter earlier this week before premiering it on US radio yesterday afternoon (October 5).
Lyrics in the track include: "Since I landed here, I gon' phone up Obama/ Shook the world up, now I caused a little drama/ Leader of the new school and yes I'm gonna/ Light up the block to the stage when I wanna."
'Fireball' follows Smith's previous singles 'Whip My Hair' and '21st Century Girl', with all three tracks to feature on the star's upcoming debut album.
Producer Ronald 'Jukebox' Jackson recently revealed that work on the child performer's first LP is coming to a close and should be available for fans soon.
Listen to 'Fireball' by Willow Smith featuring Nicki Minaj below: