The former X Factor contestants have put themselves forward to represent Switzerland in the singing competition with their new track 'Music'.
Swiss residents are able to vote for the sibling duo during their official Eurovision platform entry website along with other entrants.
The site explains that voters can submit up to four entries for the pop pairing or any other act.
Same Difference told Digital Spy earlier this year that they were depressed after being dropped from Simon Cowell's Syco record label back in 2009.
The twosome also revealed that they regretted releasing their single 'Shine On Forever (Photo Frame)' in August 2010, after it reached number 100 on the UK chart.
Listen to Same Difference's Swiss entry contender 'Music' below: