The 18-year-old has taken an early lead on the chart with her second single 'With Ur Love', pushing Professor Green's 'Read All About It' down to two.
Rihanna and Calvin Harris remain at three with 'We Found Love' while Labrinth slips down to four with 'Earthquake'.
Maroon 5 and Christina Aguilera complete the top five with 'Moves Like Jagger' and Kelly Clarkson slides down to seven with 'Mr Know It All'.
Outside the top ten, Lucenzo and Qwote's 'Danza Kuduro', which features Pitbull and Don Omar, enters at 12 and Nicole Scherzinger's new cut 'Try With Me' lands at 16.
The X Factor effect pushes Adele's 'Set Fire To The Rain' up 17 places to 19, while Katy Perry's 'E.T.' re-enters the top 40 at number 27.
Over on the album chart, Florence + the Machine are on course to nab their second UK number one album with Ceremonials.
Coldplay's Mylo Xyloto has fallen one place down to two, while Professor Green's At Your Inconvenience lands at three.
Manic Street Preachers' compilation National Treasures: The Complete Singles lands at seven and is trailed by Rizzle Kicks' debut LP Stereo Typical at eight.
> View the current singles top 100 here
Watch the music video for Cher Lloyd's 'With Ur Love' below: