The 27-year-old fought off competition from Rihanna and Calvin Harris-team up 'We Found Love' and 'Earthquake' by Labrinth and Tinie Tempah to remain head of the rankings.
Midweek number one 'With Ur Love' by Cher Lloyd finishes at four to grab the title of today's highest new entry, Ed Sheeran finally cracks the Top 10 with third single 'Lego House', up to six from 12, and Kelly Clarkson trips five to nine with 'Mr Know It All'.
'Without You' by David Guetta and Usher returns to the top-sellers at 10 from last week's 13, while elsewhere in the double digits Lana Del Rey's 'Video Games' bumps up three to 12, one position ahead of a new entry from Lucenzo & Qwote named 'Danza Kuduro'.
Gym Class Heroes and Adam Levine drop five to 15 with 'Stereo Hearts', while Rizzle Kicks lose their place in the Top 10 after falling from eight to 16 with 'When I Was A Youngster'.
Nicole Scherzinger's latest release 'Try With Me' makes its debut on the chart at 18, Cobra Starship drop four from 16 to wrap up the Top 20 with 'You Make Me Feel' and Adele leaps a mighty 15 spots to 21 with 'Set Fire To The Rain' following X Factor contestant Craig Colton's performance of the song on last week's show.
The Top 10 in full:
1. (1) Professor Green ft. Emeli Sande: 'Read All About It'
2. (3) Rihanna ft. Calvin Harris: 'We Found Love'
3. (2) Labrinth ft. Tinie Tempah: 'Earthquake'
4. (-) Cher Lloyd ft. Mike Posner: 'With Ur Love'
5. (5) Maroon 5 ft. Christina Aguilera: 'Moves Like Jagger'
6. (12) Ed Sheeran: 'Lego House'
7. (7) LMFAO: 'Sexy And I Know It'
8. (6) Charlene Soraia: 'Wherever You Will Go'
9. (4) Kelly Clarkson: 'Mr Know It All'
10. (13) David Guetta ft. Usher: 'Without You'
Source: Official Charts Company
> This week's albums chart
> Read Digital Spy's recent interview with Professor Green here