It was announced today that Ludacris will join Enrique Iglesias for a collaboration. The duet will mark the show's sixth joint performance, breaking the record for most unique collaborations.
Other collaborations include Pitbull with Marc Anthony and Lil Jon; Gym Class Heroes with Adam Levine; will.i.am with Jennifer Lopez; Nicki Minaj with David Guetta; and Maroon 5 with Christina Aguilera.
In addition, Drake will perform 'Headlines' from his new album Take Care.
Justin Bieber Kelly Clarkson and Mary J Blige will also take the stage at the awards show.
Adele leads this year's American Music Awards nominees, earning four nods for 'Artist of the Year', 'Favourite Female Artist in Pop/Rock', 'Favourite Album in Pop/Rock' and 'Favourite Artist in Adult Contemporary'.
The 2011 American Music Awards will air live from the Nokia Theatre on Sunday, November 20 at 8/7c on ABC.