The singer and his group will play headline sets at Sunderland's Stadium of Light and Manchester's Etihad Stadium in June.
They will also play London's Hyde Park as part of Hard Rock Calling the following month. Springsteen previously played the London festival in 2009.
Live Nation's vice president of promotions Toby Leighton-Pope said: "It's great to welcome Bruce Springsteen & The E Street Band back to the UK, they always put on a fantastic show."
Tickets for the the shows go on sale on Saturday, December 3 and are priced at £55 and £60 for London.
Springsteen & The E Street Band will also headline the Isle of Wight festival on Sunday, June 24.
Tickets for the event go on sale on Friday, 25 November at 9am.
The festival's promoter John Giddings said: "It's taken years to get him here, but it will have been worth the wait - he is one of the greatest acts of all time, it's going to be a classic year..."
The full tour dates are as follows:
- June 21 - Sunderland, Stadium of Light
- June 22 - Manchester, Etihad Stadium
- June 24 - Isle of Wight Festival
- July 14 - Hard Rock Calling, London Hyde Park
Clarence Clemons, the saxophonist and long-time member of The E Street Band, died in June at the age of 69.
Guitarist Steven Van Zandt admitted that the band were considering their future after his passing.
Watch Bruce Springsteen & The E Street Band perform 'Born To Run' in London's Hyde Park in 2009 below: