The 'Mirror' rapper was to perform today (Friday) in Perth, in Adelaide on Sunday (November 27) and in Melbourne on Tuesday (November 29), but has pulled out of the gigs due to scheduling conflicts.
Promoter Dainty Group has promised that Lil Wayne will make up the dates on a solo tour of Australia in 2012.
Lil Wayne's Aussie fans will still have the chance to see the musician in concert when he opens shows for Eminem in Melbourne and Sydney next month.
Last week, Lil Wayne visited New Orleans to hand out turkeys to the less fortunate in honour of Thanksgiving.
His ninth studio album Tha Carter IV topped the US album chart upon release in August.
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Watch Lil Wayne's 'John' music video below (explicit content):