The singer has teamed up with Lil Wayne, Wiz Khalifa, TI and Andre 3000 for 'Sleazy Remix 2.0 (Get Sleazier)', which will be available to download in the US on December 13.
Before revealing part of the track via Twitter, Ke$ha asked her fans: "Question ANIMALS... who can say they got with Lil Wayne, T.I., Andre 3000 and Wiz Khalifa on a f**king hot track?? I'll give u one clue...... It's $ (sic)"
The original version of 'Sleazy' featured on Cannibal, which is an expanded edition of the star's debut album Animal.
Ke$ha is currently working on the follow-up to her debut album and has previously told Digital Spy that she plans to thread "a lot of guitar" through her new material.
The singer has also claimed that her ultimate goal is to reinvent pop with her new set and credited meeting Alice Cooper as her inspiration to evolve her sound.
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Listen to Ke$ha's 'Sleazy Remix 2.0 (Get Sleazier)' below: