The X Factor winners have topped the midweek chart with their debut single 'Cannonball', while Coldplay trail at two with 'Paradise'.
Leona Lewis's 'Hurt' completes the top three, while Sunday's number one 'Dance With Me Tonight' by Olly Murs slip to four.
Rihanna is at five with 'We Found Love', Mariah Carey at seven with 'All I Want For Christmas Is You' and T-Pain dips to 10 with '5 O'Clock'.
Damien Rice's original version of 'Cannonball' currently resides at 12, while the X Factor finalists' charity single 'Wishing On A Star' plummets to 13.
En Vogue's 'Don't Let Go (Love)' re-enters at 17, Kelly Rowland's 'Down For Whatever' is at 23 and Beyoncé's 'Love On Top' is at 28.
Over on the album chart Michael Buble is at number one with his festive album Christmas, pushing Amy Winehouse's Lioness: Hidden Treasures down to two.
> View the current singles top 100 here
Watch Little Mix perform 'Cannonball' live on The X Factor below: