The 'Hit The Lights' singer and her band The Scene will perform at the House of Blues in West Hollywood, California on Friday, January 20.
Fan club tickets go on sale today (January 5) from 10am PT through her official website, with general public tickets then available from January 6 at 5pm PT through Ticketmaster.
Gomez teased the event on her Twitter account, writing: "Have some surprise guests lined up for the UNICEF charity show... can't wait to share them with you."
She added in a statement to her website: "Giving back has always been important to me. This concert allows me to connect with my fans in person which is one of the best parts of my job and to raise money for important causes at the same time. I can't think of anything I would enjoy doing more."
The 19-year-old singer and actress has been a UNICEF Ambassador since 2009, working to raise awareness of the issues facing vulnerable children across the world.
Gomez released third studio album When The Sun Goes Down last year, which has already spawned the singles 'Who Says', 'Love You Like A Love Song' and 'Hit The Lights'.
Watch Selena Gomez's video for 'Love You Like A Love Song' below: