The singer has enlisted the help of Chambers - whose previous collaborators include Robbie Williams and Kylie Minogue - for the follow-up to her 2011 debut On A Mission, reports Contact Music.
The star - whose full name is Katy Brien - recently admitted that she hasn't had time to write new material for her next collection, but has made notes for ideas.
Katy B explained: "I haven't had time to write yet. Some people do it on tour, but I always I have to be more focused to lay down the ideas."
However, it is not known whether the new material with Chambers could be included on a deluxe edition of On A Mission, which the performer has previously hinted at.
She told Digital Spy: "We're maybe going to do a deluxe version of On A Mission so a couple of tracks I've been working on will probably go on that. There won't be loads of new songs, just a couple."
> Katy B hits Ibiza in 'Movement' music video
Watch the music video for Katy B's hit 'Lights On' below: