The rapper tops the tally with 'Good Feeling', keeping Olly Murs at two with 'Dance With Me Tonight'.
Jessie J's 'Domino' rockets up 32 places to number three on the chart, while Little Mix fall to four with 'Cannonball' and Rihanna is at five with 'We Found Love'.
Outside the Top 10, Lloyd is at 11 with 'Dedication To My Ex', Rizzle Kicks vault up to 17 with 'Mama Do The Hump' and Taio Cruz climbs to 25 with 'Troublemaker'.
Beyoncé is at 28 with 'Love On Top', Pitbull is at 29 with new cut 'International Love' and Coldplay enter the chart at number 40 with their new single 'Charlie Brown'.
This week's Irish Top 10 is as follows:
1. (5) Flo Rida: 'Good Feeling'
2. (2) Olly Murs: 'Dance With Me Tonight'
3. (35) Jessie J: 'Domino'
4. (1) Little Mix: 'Cannonball'
5. (3) Rihanna feat. Calvin Harris: 'We Found Love'
6. (4) Coldplay: 'Paradise'
7. (9) Lana Del Rey: 'Video Games'
8. (8) LMFAO: 'Sexy And I Know It'
9. (7) Florence + The Machine: 'Shake It Out'
10. (6) Ed Sheeran: 'Lego House'
Watch the music video for Flo Rida's 'Good Feeling' below: