The duo, who have been nominated for 'Best British Band' at this year's Brit Awards, will DJ at the event, held in Croatia between June 29 and July 1.
The pair are joined by drum & bass acts Skream, Skrillex, SBTRKT, Shy FX and Simian Mobile Disco.
Tiga, Seth Troxler and German act Loco Dice will also perform sets at the three-day festival.
Tickets for the Hideout Festival, which cost £99 for the whole event, are on sale now.
Download Festival organiser Andy Copping recently insisted that Chase & Status will "win people over" with their set, adding: "I know they're going to step up and win people over. I saw them perform in Hyde Park last year and they totally blew me away with the intensity of their show."
> Chase & Status: 'Nero should have won Brit Breakthrough Award'
Watch the music video for Chase & Status' 'Flashing Lights' below: