Titled 'Love Interruption', the single went online today at his website www.jackwhiteIII.com.
A digital version of 'Love Interruption' will be available for purchase tonight at 9pm PST worldwide, excluding Europe.
A vinyl version of the single, which features the B-side 'Machine Gun Silhouette', will be sold on February 27.
Blunderbuss, which was produced by White and recorded at his Third Man Studio in Nashville, will drop in stores on April 24.
White has described Blunderbuss as "an album [he] couldn't have released until now".
He added: "I've put off making records under my own name for a long time but these songs feel like they could only be presented under my name. These songs were written from scratch, had nothing to do with anyone or anything else but my own expression, my own colours on my own canvas."
White recently collaborated with the legendary Tom Jones on another project for his music label Third Man Records.
White's band with Meg White, The White Stripes, announced their split last year "to preserve what is beautiful and special about the band".
Listen to Jack White's 'Love Interruption' below: