Out of the Game will be released on April 23 through Polydor, and has been produced by Mark Ronson.
Wainwright describes the LP as his "most pop" record to date, while Ronson has said that it contains the best production work of his career.
Sean Lennon, Martha Wainwright and Andrew Wyatt of Miike Snow are among the artists who also contributed to the album.
Rufus Wainwright became engaged to long-term partner Jorn Weisbrodt last year.
Mark Ronson first revealed that he would be working with Wainwright in February last year.
The full tracklisting for Out of the Game:
1. Out of The Game
5. Welcome To The Ball
7. Bitter Tears
8. Respectable Dive
9. Perfect Man
10. Sometimes You Need
11. Song Of You
Watch the video for Rufus Wainwright's 'Going to a Town' below: