The two-day event - which marks the run-up to the London 2012 Olympics - is to be held in Hackney Marshes on the weekend of June 23-24.
Other participating acts unveiled by Radio 1 today (February 3) include Emeli Sande, Professor Green, Taio Cruz, Dappy, David Guetta, Jack White and Rizzle Kicks.
Calvin Harris, Chase & Status, Labrinth, Wretch 32, The Ting Tings and The Maccabees are also among the 34-strong line-up.
Leona Lewis, Plan B, Tinie Tempah and Florence + the Machine were all confirmed to be playing at the event late last year.
More acts are set to be announced in the future.
Radio 1's Hackney Weekend will be the biggest concert in the broadcaster's history, with over 100,000 people gathering to see the 80-plus acts assembled.
Fans have until March 19 to register for free tickets on the Radio 1 website.
Watch Ed Sheeran's video for 'Lego House' below: