The singer admitted that he is aware that dozens of girls are carried out of the audience on a regular basis at their shows, reports The Sun.
Talking on BBC Two's new documentary I'm In A Boy Band, Humes explained: "It still bothers me when lots of girls faint and when you see dozens and dozens of girls being carried over the barriers."
He added: "You kind of feel guilty and think 'We have caused that'."
JLS will embark on their '4th Dimension' UK headline tour next month, starting at Liverpool's Echo Arena on March 13.
I'm In A Boy Band will air on BBC Two later this month.
> JLS interview: 'We'd like to work with Adele on new album'
Watch the music video for JLS's Sport Relief charity single 'Proud' below: