Two Door Cinema Club, The Horrors, Justice, Sigur Ros and Azealia Banks are among the new raft of names confirmed to play the festival between September 6-9.
Other sets will come from De La Soul, Charli XCX, Nero, Warpaint, Gary Numan and Major Lazer.
Festival organiser Rob Da Bank revealed that The xx and Sigur Ros will make their only UK festival appearances at Bestival in 2012.
The music event will take place at Robin Hill Park on the Isle Of Wight, with tickets on sale now.
It was recently announced that Orbital will serve as the Big Top headliners at this year's Bestival.
Watch the music video for Emeli Sandé's 'Next To Me' below: