They are joined by Azealia Banks, Noah and the Whale, Justice, Crystal Castles, Claude Von Stroke, De La Soul, Annie Mac, The Rapture, DJ Yoda, Erol Alkan, Jaques Lu Cont, Delilah, Goldie and many more at the event, which takes place on June 9 and 10 at Platt Fields Park, Fallowfield.
Tickets are available now and are priced at £64.50 including booking for the weekend. Saturday only tickets are £38.50 and Sunday only tickets £38.50.
Festival-goers are not allowed to camp at the site and must leave at 11pm when it closes each night.
Last year's Parklife featured performances from Katy B, Kelis, Chase and Status, Mark Ronson and the Mystery Jets.
> Flaming Lips' Wayne Coyne wants Henry Rollins on Ke$ha collaboration
Watch the video trailer for the Parklife 2012 weekender below:
Watch The Flaming Lips perform 'Do You Realise??' live at Glastonbury 2010 below: