In an online broadcast, the London-born singer won both 'Best Pop Vocal Album' for 21 and 'Best Short Form Music Video' for 'Rolling In The Deep'.
Adele will perform during the ceremony, her first live TV appearance since undergoing throat surgery. She is nominated in a further four categories: 'Record Of The Year', 'Song Of The Year', 'Album Of The Year' and 'Best Pop Solo Performance'.
Also a double winner, Taylor Swift collected the 'Best Country Song' and 'Best Country Solo Performance' award for her single 'Mean'.
Mitch and Janis Winehouse joined Tony Bennett on stage to collect the 'Best Pop Duo/Group Performance' award for duet 'Body and Soul', which was released after the 27-year-old's death last year.
The Foo Fighters picked up four early awards, including; 'Best Rock Album' for Wasting Light, Best Rock Song for 'Walk' and 'Best Hard Rock/Metal Performance' for 'White Limo' and '78. Best Long Form Music Video' for 'Back and Forth'.
Stay tuned to Digital Spy for live, complete coverage of the Grammy Awards.
> Adele: 'Grammy nominations are an honour'
> Jennifer Hudson 'breaks down in Whitney Houston Grammy rehearsal'
Watch Adele's 'Someone Like You' video below: