The two singers took the stage at the awards show to pay tribute to the late singer, who passed away in January at the age of 73.
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Keys and Raitt performed James's classic song 'A Sunday Kind of Love'.
James died in a hospital in Riverside, California following a two-year battle with leukemia.
Keys also paid tribute to Whitney Houston, who was found dead on Saturday (February 11) afternoon.
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> Grammy Awards 2012: The Band Perry, Blake Shelton join Glen Campbell
> Grammy Awards 2012: Katy Perry performs new single 'Part of Me'
> LL Cool J prays for Whitney Houston at Grammy Awards
> Grammy Awards 2012: The major winners