The 'Holiday' rapper will be the main act for the event on June 3, while electronic act Deadmau5 will headline the closing night on June 4.
Maximo Park, Noah and the Whale, Rizzle Kicks and Miles Kane are among the other acts performing over the weekend at Gateshead Quayside.
Dizzee Rascal is currently working on the follow-up to his 2009 LP Tongue N' Cheek, and has described the new record as "fun and worldly".
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The Evolution Festival lineup in full so far is as follows:
Benjamin Francis Leftwich
Dog Is Dead
The Lake Poets
Noah and the Whale
Band Of Skulls
Here We Go Magic
Totally Enormous Extinct Dinosaurs
Maya Jane Coles
People Get Real
Watch the video for Deadmau5's 'I Remember' below: