The singer's third cut from new album Our Version Of Events pushed Gotye's 'Somebody That I Used To Know' down to number two.
Flo Rida remains at three with 'Wild Ones', Jessie J's 'Domino' slips to four and David Guetta's 'Titanium' sits at five.
One Direction's new single 'One Thing' vaults up 18 places to number six, while Kelly Clarkson's 'Stronger' slides one spot down to seven.
Whitney Houston's 'I Will Always Love You' re-enters at 13 following her tragic death last Saturday (February 11).
Gym Class Heroes' 'Ass Back Homed' drops to 18, and Madonna's latest cut 'Give Me All Your Luvin'' plummets to number 26.
Houston's 'I Wanna Dance With Somebody' is at 32, DJ Fresh's 'Hot Right Now' premieres at 34 and Pixie Lott's 'Kiss The Stars' is at 40.
This week's Irish Top 10 is as follows:
1. (-) Emeli Sandé: 'Next To Me'
2. (1) Gotye feat. Kimbra: 'Somebody That I Used To Know'
3. (3) Flo Rida feat. Sia: 'Wild Ones'
4. (2) Jessie J: 'Domino'
5. (4) David Guetta feat. Sia: 'Titanium'
6. (24) One Direction: 'One Thing'
7. (6) Kelly Clarkson: 'Stronger'
8. (14) David Guetta feat. Nicki Minaj: 'Turn Me On'
9. (5) Rizzle Kicks: 'Mama Do The Hump'
10. (9) Lana Del Rey: 'Video Games'
Watch the music video for Emeli Sandé's 'Next To Me' below: